MANCHESTER — The main Manchester health clinic that serves poor and uninsured residents plans to open a satellite operation in the center city, after receiving a $650,000 federal grant, officials said Wednesday.

The grant was one of 219 announced Wednesday by U.S. Secretary of Health and Human Services Kathleen Sebelius. Nationally, $128.6 million is being distributed.

“This funding will greatly benefit the community and make a real difference in the day-to-day lives of the residents of the service area, allowing us to serve an additional 4,500 patients,” said Ed George, president and chief executive of Manchester Community Health center.

He said the office will provide primary health, dental health and mental health services at the Easter Seals building on Auburn Street. George expects the health center will hire 20 to 25 people in the new office; nationally, Sebelius predicts 5,640 new jobs.

“The health care law is making our community health centers stronger and ensuring more Americans get the care they need,” Sebelius said in prepared remarks.

The operation will be a collaboration among the health center, Easter Seals, and the Mental Health Center of Greater Manchester.