BOSTON — In their first meeting of the season, the Angels beat the Red Sox, 5-3, at Fenway Park Tuesday night.

Right-hander Ervin Santana earned the win, going 6 1/3 innings and giving up two runs on five hits and two walks with four strikeouts. He improved to 7-10, with a 5.46 ERA.

Red Sox right-hander Aaron Cook took the loss. He went five innings, giving up five runs (four earned) on a season-high 11 hits and a walk with a season-high four strikeouts. His record fell to 3-7 as his ERA rose to 4.79.

The Angels got a run in the third when Mike Trout hit a one-out single to center, taking second on Cook’s errant pick-off attempt. With two outs, Trout scored on Albert Pujols’ single to center.

In the fourth, the Angels sent seven batters to the plate with five reaching base on consecutive hits, all singles. After Mike Trumbo struck out to open the inning, Howie Kendrick singled to right and Alberto Callaspo singled to left. Kendrick scored on Erick Aybar’s single to right, with Aybar thrown out trying to stretch it into a double. Chris Iannetta’s single to shortstop scored Callaspo. Trout singled before Torii Hunter hit into a fielder’s choice.

The Angels added two runs in the fifth when Trumbo’s 30th home run of the season cleared the left field wall, scoring Kendrys Morales, who had singled to center.

Meanwhile, the Sox had little offense against Santana until the sixth inning, when Boston scored a pair of runs on Jarrod Saltalamacchia’s 21st home run of the season, which also scored Cody Ross, who had walked with two outs, cutting the Angels lead to 5-2.

The Sox added a run in the seventh off reliever Jordan Walden. Scott Podsednik doubled to left, going to third on Pedro Ciriaco’s groundout, and scoring on a wild pitch with Dustin Pedroia batting.

Ernesto Frieri earned his 15th save with a perfect ninth.

The win snapped a four-game losing streak for the Angels.

- - - - - - -

NOTES: Boston right-hander Vicente Padilla was activated from the disabled list prior to the game. He had been on the DL since Aug. 6 with right arm tightness. To make room on the roster for him, third baseman Danny Valencia was optioned to Triple-A Pawtucket...Outfielder Daniel Nava, on the DL since July 29 with a left wrist sprain, was activated...Jacoby Ellsbury was batting third in the Red Sox lineup for the first time this season, after hitting either first or second all season. He has played in just 42 games because of injuries, batting .250 with one home run, 24 runs scored, and 11 RBIs...The Red Sox have had 49 players appear in a game this season, matching their entire 2011 total. It’s the third-most in the majors this season behind Toronto (51) and San Diego (50)...Trout scored the first run of the game. It was his 97th run in his 100th game of the season. The only player with more runs scored in his first 100 games was Joe DiMaggio with 100 runs in 1936...Trout entered the game leading the American League in average, at .343, and stolen bases, with 39. Only two players (one rookie) in the last 63 years have led a league in both categories — Ichiro Suzuki in 2001 (.350, 56) and Jackie Robinson in 1949 (.342, 47). Trout also leads the majors in runs scored....Hunter entered the game hitting in 14 of 17 games this month, batting .356, going 26-for-73...This is Pujols’ first appearance at Fenway Park since the 2004 World Series, first time in the regular season since June 10-12, 2003.