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Buchholz stays unbeaten in Red Sox win
Stephen Drew, Daniel Nava and Mike Carp also homered for the Red Sox (19-8) before a crowd of 21,094 at Rogers Centre.
Buchholz (6-0), whose best outing this season came on April 14 when he allowed two hits and struck out 11 over eight innings in a 5-0 win over the Tampa Bay Rays, lowered his earned-run average to 1.01 with Wednesday's outing.
The right-hander has won 10 of his past 13 starts against the Blue Jays (10-18) dating to July 17, 2009.
He allowed three walks and struck out eight before being replaced by right-hander Alex Wilson after seven innings and 101 pitches.
The Blue Jays' first hit was Munenori Kawasaki's single to center with one out in the third. Their next hit was a single to right with one out in the seventh by Melky Cabrera, who was out trying for a double while Adam Lind, who had walked, reached third.
Blue Jays left-hander Mark Buehrle (1-2) allowed seven hits (including three home runs), three walks and five runs over 6 2/3 innings.
He left for Esmil Rogers after walking Jonny Gomes in the seventh. Rogers gave up a single to Dustin Pedroia that sent Gomes to third and a run then scored on a wild pitch. After David Ortiz was walked intentionally, Napoli hit a mammoth home run to center field to plate three runs. It was his sixth of the season.
The Blue Jays scored against Wilson in the eighth on a single by Maicer Izturis and a triple by Brett Lawrie.
Carp hit his second homer of the season as a pinch-hitter in the ninth against Justin Germano. A double by Napoli and single by Nava made the score 10-1.
The Red Sox took a 2-0 lead in the second when Drew's first home run of the season came after Will Middlebrooks was hit by a pitch with two outs.
The Red Sox built the lead to 4-0 on consecutive homers in the fourth by Napoli and Nava.
Notes: Blue Jays right-hander R.A. Dickey (upper back) had an MRI that showed inflammation. He pitched a side session on Wednesday and will start Saturday against the Seattle Mariners. ... Right-hander Josh Johnson (strained triceps) is expected to be ready for his start on Friday against the Mariners. ... Red Sox center fielder Shane Victorino (lower back tightness) did not start for the sixth game in a row. ... Right-hander Ryan Dempster (1-2, 3.30 ERA) will start for Boston in the series finale today against left-hander J.A. Happ (2-1, 3.86). ... Dempster, who is from Sechelt, B.C., will be making his first career appearance in Toronto and his fourth appearance against the Blue Jays.