UNH researcher Mao Chen

University of New Hampshire researcher Xuanmao (Mao) Chen found that neurons become more synchronized when a memory is being formed in so-called Pavlovian learning.

DURHAM — The phrase “Pavlov’s dogs” has long evoked images of bells, food and salivating dogs.

Even though this tried-and-true model of repetitive patterns mimics a variety of learning processes, what happens on a cellular level in the brain isn’t clear.

Researchers at the University of New Hampshire took a closer look at the hippocampus, the part of the brain critical for long-term memory formation, and found that the neurons involved in so-called Pavlovian learning shift their behavior during the process and become more synchronized when a memory is being formed.

According to a UNH news release, this finding helps people better understand memory mechanisms and it provides clues for the development of future therapies for memory-related conditions like dementia, autism and post-traumatic stress disorder.

“There are tens of millions of neurons in the hippocampus but only a small fraction of them are involved in this learning process” said Xuanmao (Mao) Chen, assistant professor of neurobiology.

“Before engaging in Pavlovian conditioning, these neurons are highly active, almost chaotic, without much coordination with each other, but during memory formation they change their pattern from random to synchronized, likely forging new connecting circuits in the brain to bridge two unrelated events.”

In the study, recently published in The FASEB Journal, researchers looked at Pavlovian learning patterns, or respondent conditioning, in mice.

In the beginning, before any repetitive learning exercises, the mice did not know what to expect and using special imaging with an endomicroscope the researchers saw that the neural activity was disorderly, the news release says.

But after repeating different tasks associated with a conditional stimulus, like a tone or bell, the mice began to recognize the pattern and the highly active neurons became more synchronized. The UNH researchers hypothesize that without forming synchronization, animals cannot form or retrieve this type of memory.

In the 1890s, Russian psychologist Ivan Pavlov discovered classical conditioning through repetitive patterns of bell ringing which signaled to his dogs that food was on its way and stimulated salivation.

This same learned behavior is important for episodic knowledge which is the basis for such things as learning vocabulary, textbook knowledge and memorizing account passwords, the UNH press release states. Abnormal learning processing and memory formation are associated with a number of conditions like dementia, autism and PTSD.

People who struggle with these cognitive dysfunction-related disorders may have trouble retaining memories or can even form too strong a memory, as with PTSD patients. The UNH researchers believe that understanding the fundamentals of how classical conditioning shape neural connections in the brain could speed up the development of treatments for these disorders in the future.

Contributing to these findings are Yuxin Zhou, doctoral candidate at UNH; Liyan Qiu, research scientist at UNH; and Haiying Wang, assistant professor at the University of Connecticut.

This work was supported by the National Institutes of Health and the Cole Neuroscience and Behavioral Faculty Research Awards.

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