HAMPTON — Grammy- and Oscar-winning singer and songwriter Melissa Etheridge can’t wait to return to the Seacoast.

“What a great time I have playing the Hampton Beach Casino (Ballroom). It’s a great venue,” Etheridge said.

She first played the historic beachside hall in 1989. Next Wednesday, Aug. 21, she brings her new album to the loyal fans who turn out to see her play.

Etheridge said “The Medicine Show” is a collection of songs close to her heart. It was released by Concord Records in April.

“I’m 58. I’m on the other side of a lot of things. You’re not going to hear me wailing about the pain of love lost. There’s a certain knowledge you get as you grow,” she said.

Etheridge calls “I Know You” her “grown-up love song.” It’s her favorite track on the album and is about fighting with her wife (Linda Wallem) and getting over it in the morning, knowing neither to them is going anywhere.

“The Medicine Show” also deals with other universal themes such as national anxiety (“Shaking”) and the opioid crisis (“Here Comes the Pain”). “Last Hello” is about the courage shown by the survivors of the Parkland school shootings.

Etheridge has said “The Medicine Show” is about health, wellness and cannabis.

“It influences every song on the album. We’re not afraid of this anymore. We’ve come a long way,” Etheridge said.

Etheridge said in her interview with the New Hampshire Union Leader that she is feeling great. She is 15 years cancer-free ’and loving her career.

One of the most fulfilling things she sees out on the road is another generation of fans — all the young people whose parents listened to her when they were kids.

“It’s really cool. The energy is still high, and people are still enjoying the songs,” Etheridge said.