Carson Wentz threw three touchdown passes and rallied the host Philadelphia Eagles from an early 17-point deficit for a season-opening 32-27 victory over the Washington Redskins on Sunday afternoon.
Wentz was 28 of 39 for 313 yards with a pair of 50-plus touchdown passes to DeSean Jackson. It was Wentz’s first game in nine months while he recovered from a stress fracture in his back.
Jackson had eight catches for 154 yards.
Case Keenum finished 30 of 45 for 380 yards and three touchdown passes in his first start for the Redskins.
Titans 43, Browns 13: Marcus Mariota threw for three touchdowns, Derrick Henry scored twice and visiting Tennessee clamped down on error-prone Cleveland.
Mariota completed 14 of 24 passes for 248 yards, hitting all six of his second-half passes for 143 yards. He broke the game open in the fourth quarter with scoring strikes of 11 and 7 yards to tight end Delanie Walker.
Both of those scores came off short fields after interceptions of Baker Mayfield, temporarily deflating the high hopes of Browns fans looking for the team’s first division title since this version of the franchise was founded in 1999. Mayfield hit 25 of 38 throws for 285 yards and a score.
Rams 30, Rams 27: Malcolm Brown scored on a pair of short touchdown runs, and the defending NFC champion Los Angeles Rams overcame some missed scoring chances to defeat host Carolina.
Rams quarterback Jared Goff was 23 for 39 for 186 yards with a touchdown and an interception.
Vikings 28, Falcons 12: Dalvin Cook ran for 111 yards with two touchdowns and safety Anthony Harris recorded two interceptions and recovered a fumble as host Minnesota rolled past Atlanta.
Kirk Cousins (8 for 10, 98 yards) threw for a touchdown and ran for another as the Vikings scored TDs on three of their first four possessions. Minnesota recorded all of its points off three Atlanta turnovers and a blocked punt.
Cook, limited to 15 games over his first two seasons because of injuries, ran the ball 21 times and had 40 yards on his first two carries.
Atlanta’s Matt Ryan was 33 of 46 for 304 yards with fourth-quarter touchdown passes to Calvin Ridley and Julio Jones. However, Ryan was intercepted twice and sacked four times.
Chiefs 40, Jaguars 26: Kansas City quarterback Patrick Mahomes, the NFL’s reigning Most Valuable Player, passed for 378 yards and three touchdowns as the Chiefs toppled host Jacksonville.
Playing on a heavily wrapped left ankle he sprained in the first quarter, Mahomes drove Kansas City to scores on each of its first seven possessions while going 25 of 33 with no interceptions. His favorite target was Sammy Watkins, who snagged nine receptions for 198 yards and scored on all three of Mahomes’ touchdown passes.
Watkins enabled Kansas City to overcome the loss of Tyreek Hill, who signed a three-year contract extension late last week but left in the first quarter with a shoulder injury.
Ravens 59, Dolphins 10: Lamar Jackson tied a franchise record with five touchdown passes as his Baltimore Ravens routed host Miami.
Jackson, who led all NFL quarterbacks last year with 695 rushing yards in just seven starts, spent the offseason working on his passing, and it was evident on Sunday. He completed 17 of 20 attempts for 324 yards with no interceptions.
Thanks in part to Jackson, the Ravens also set a franchise record for most points in one game. Baltimore tied for the second-most points ever in an NFL season opener, trailing the 1973 Atlanta Falcons (62).
Forty-Niners 31, Bucs 17: San Francisco 49ers returned two interceptions for touchdowns, and Jimmy Garoppolo passed for another.
Richard Sherman and Ahkello Witherspoon scored the Niners’ touchdowns on defense after both intercepted Bucs quarterback Jameis Winston. San Francisco recorded two interceptions on defense all of last season.
Cowboys 35, Giants 17: Dak Prescott tied a career high with four touchdown passes and threw for 405 yards as host Dallas overcame an early deficit and rolled past the New York Giants.
Prescott completed 25 of 32 passes and produced his second career 400-yard game. Prescott finished 50 yards shy of his career-high set against Philadelphia last season.
Seahawks 21, Bengals 20: Russell Wilson hit Tyler Lockett with a 44-yard touchdown pass on the first play of the fourth quarter and host Seattle Seahawks held on to beat Cincy.
Cincinnati’s Andy Dalton completed 35 of 51 passes for 418 yards, a franchise record for a season opener, with two touchdowns. But the Bengals weren’t able to get past midfield in their last two possessions.
Chargers 30, Colts, OT: Austin Ekeler’s third touchdown of the day, a 7-yard run with 5:01 left in overtime, lifted the host Los Angeles Chargers.
Starting in place of holdout Melvin Gordon, Ekeler rushed for 58 yards on 12 carries while catching six passes for 96 yards and two scores.
Veteran quarterback Philip Rivers hit on 25 of 34 passes for 333 yards and three touchdowns with one interception.
Cardinals 27, Lions 27 (OT): Host Arizona scored the last 18 points in the fourth quarter and each team’s kicker converted a field goal in overtime as the game ended in a tie.
Indianapolis forced overtime with 38 seconds left on a 19-yard touchdown pass from Jacoby Brissett to T.Y. Hilton, followed by a 2-point conversion run from Marlon Mack.